phase iii
Definition
Noun: - A large-scale clinical trial of a medical treatment or drug, conducted after preliminary phases (Phase I and Phase II) have demonstrated the treatment's efficacy and acceptable side effects. The successful completion of this phase is typically required for the treatment to receive formal regulatory approval (e.g., from the FDA).
Usage
This term is used specifically in the context of medical research and drug development. - The new cancer therapy is entering a phase III trial to confirm its effectiveness in a larger patient population. - Before a drug can be marketed, it must successfully pass phase III clinical testing.
Advanced Usage
- "phase III study": A common collocation emphasizing the research nature of the trial.
- The results of the phase III study were published in a leading medical journal.
- "phase III trial": A synonymous collocation frequently used interchangeably with "phase III study."
- The randomized, double-blind phase III trial involved over 3,000 participants.
Variants and Related Words
- Phase I (n): An initial clinical trial testing a new drug or treatment in a small group of people to evaluate safety, dosage, and identify side effects.
- Phase II (n): A clinical trial where the treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
- Phase IV (n): Post-marketing surveillance studies conducted after a treatment has been approved and marketed to gather additional information on risks, benefits, and optimal use.
- Clinical trial (n): A research study performed on human volunteers to evaluate medical, surgical, or behavioral interventions.
Synonyms
- Pivotal trial: A trial that provides the definitive evidence of a treatment's efficacy and safety, often synonymous with a Phase III trial in the context of regulatory submission.
- Confirmatory trial: A trial designed to confirm the therapeutic benefits suggested in earlier studies.
Related Phrases
- To advance to phase III: To progress to this stage of testing after successful earlier phases.
- The vaccine candidate showed promising results and will advance to phase III next year.
- Phase III data: The results and findings from a Phase III trial.
- The company's stock price rose sharply following the release of positive phase III data.
Noun
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a large clinical trial of a treatment or drug that in phase I and phase II has been shown to be efficacious with tolerable side effects; after successful conclusion of these clinical trials it will receive formal approval from the FDA
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